Latest headlines

Loading...

Learn about Erectile Dysfunction and Sildenafil Citrate Online

Have you ever wondered how sildenafil acts within your body to help you solve your problems with erectile dysfunction?  Thanks to the instant availability of the Internet and computer devices, you will now be able to learn about ED and sildenafil citrate online right at your fingertips.

If you are curious as to how PDE5 inhibitors such as sildenafil work inside your body, then you can browse on search engines by simply typing in the search box the words sildenafil citrate online.  When you read about the mechanics of the action of sildenafil citrate online, you will learn that it helps protect the enzyme cGMP (short for cyclic guanosine monophosphate) from being degraded by the cGMP-specific PDE5 (short for phosphodiesterase type 5 enzyme) which are evidently located in the penile corpus cavernosum of men.  The free radical NO (short for nitric oxide) found in the penile corpus cavernosum adheres itself to what are called the guanylate cyclase receptors, which then results to the occurrence of elevated amounts of cGMP, thereby leading to the vasodilation or relaxation of the smooth muscles of the inner lining cushions of the helicine arteries (tendril-like arteries of the penis importantly involved in the process of its erection).  Once the smooth muscles relax, it will result to vasodilation and therefore there will be an increased supply of blood flowing into the penile spongy tissue, and the end result would be a successful penile erection.

Additionally, what you would also learn about sildenafil citrate online is that its special molecular makeup is somewhat similar to cGMP (located in the penile corpus cavernosum as well) and functions as an aggressive binding element of PDE5 in the penile corpus cavernosum, which results to more concentrations of cGMP and even better occurrences of erections. Avery important information that men will learn through reading about sildenafil citrate online is that sildenafil will be rendered useless without the introduction of one or more sexual stimuli, since only a sexual stimulus will be the only factor that can initiate the activation of the nitric oxide and cGMP inside a man’s body. Read more…

What really killed Jane Austen?

Was it the vapours? Acute Darcyitis? A bilious attack?

What really killed Jane Austen?

In honour of PBS's Masterpiece Theatre Complete Jane Austen series, here's a little survey for all you medical detectives out there on what killed the beloved author of Pride and Prejudice et al at just 41 years of age.

Addison's disease, first diagnosed by Sir Zachary Cope in the British Medical Journal in 1964, is Jane Austen's most commonly accepted cause of death. Leukemia, Hodgkin’s disease, non Hodgkin’s lymphoma, tuberculosis and systemic vasculitis, among others, have also been cited as possibilities. Hodgkin's disease is argued for in a recent survey of Austen's medical history, published in the journal Medical Humanities in 2005 by English lit prof Annette Upfal of the University of Queensland.

There's precious little information for medical historians to go on, since the bulk of Jane Austen's correspondence was famously burned by her family. Here's what we know:

Fatal illness: In her last illness, thought to begin around a year before her death, Jane Austen exhibited the following symptoms: gastro-intestinal irritation (which she characterized as "bile" or "bilious attacks"), fever, weakness, languor, knee/leg pain (which she calls "rheumatism" in her letters), possible pruritis (skin itch), insomnia, pallor, syncope, skin discoloration ("black and white and every wrong colour" she wrote to her niece).

Medical history: Jane Austen was born four weeks post-date; she suffered "putrid fever" (typhus) as a child; as a young woman she had a bout of whooping cough accompanied by otitis externa.

Chronic conditions: Ms Austen also suffered throughout her life from chronic conjunctivitis (pink eye) as well as severe trigeminal neuralgia (in her case, pain in the cheek and upper jaw).

So, medical detectives, based on her symptoms and medical history, what do you think Jane Austen died from?

What did Jane Austen die from?
Survey by Quibblo

Portrait of Jane Austen by Cassandra Austen

Check out our website: www.nationalreviewofmedicine.com

2 comments:

  1. Mr. BingleyMarch 18, 2008 at 9:52 PM

    George Wickham.

    Delete
  2. AnonymousJanuary 4, 2012 at 5:50 PM

    I think it's quite obvious what Jane Austen died from. She had the classic symptoms of non-Hodgkins lymphoma, caused by undiagnosed coeliac disease. All her symptoms point to this. The cancer probably spread to her kidneys and therefore the Addisons-like symptoms towards the end. All Jane Austen had to do was stop eating grain of any kind. Just think, if this knowledge had been available at the time......................

    Delete

Newer Post Older Post Home