Learn about Erectile Dysfunction and Sildenafil Citrate Online

Have you ever wondered how sildenafil acts within your body to help you solve your problems with erectile dysfunction?  Thanks to the instant availability of the Internet and computer devices, you will now be able to learn about ED and sildenafil citrate online right at your fingertips.

If you are curious as to how PDE5 inhibitors such as sildenafil work inside your body, then you can browse on search engines by simply typing in the search box the words sildenafil citrate online.  When you read about the mechanics of the action of sildenafil citrate online, you will learn that it helps protect the enzyme cGMP (short for cyclic guanosine monophosphate) from being degraded by the cGMP-specific PDE5 (short for phosphodiesterase type 5 enzyme) which are evidently located in the penile corpus cavernosum of men.  The free radical NO (short for nitric oxide) found in the penile corpus cavernosum adheres itself to what are called the guanylate cyclase receptors, which then results to the occurrence of elevated amounts of cGMP, thereby leading to the vasodilation or relaxation of the smooth muscles of the inner lining cushions of the helicine arteries (tendril-like arteries of the penis importantly involved in the process of its erection).  Once the smooth muscles relax, it will result to vasodilation and therefore there will be an increased supply of blood flowing into the penile spongy tissue, and the end result would be a successful penile erection.

Additionally, what you would also learn about sildenafil citrate online is that its special molecular makeup is somewhat similar to cGMP (located in the penile corpus cavernosum as well) and functions as an aggressive binding element of PDE5 in the penile corpus cavernosum, which results to more concentrations of cGMP and even better occurrences of erections. Avery important information that men will learn through reading about sildenafil citrate online is that sildenafil will be rendered useless without the introduction of one or more sexual stimuli, since only a sexual stimulus will be the only factor that can initiate the activation of the nitric oxide and cGMP inside a man’s body. Read more…

Get ready for the H1N1 flu's second wave: Butler-Jones

The good news is that the vast majority of the pandemic H1N1 flu cases in Canada have been mild and the number of fatalities has been held to fewer than 70 as of late summer. The bad news is that we probably haven't seen the worst of it yet.

Dr David Butler-Jones, the nation's first Chief Public Health Officer, is leading the Public Health Agency of Canada's preparations for the anticipated second wave of pandemic H1N1 flu, expected to arrive this fall with the potential to cause far greater damage than the virus has caused so far. He spoke with Parkhurst Exchange about what physicians need to know.

To read the online-only full version of the Q&A, click .

Photo: Public Health Agency of Canada

Good or bad? Assessing recessions' health effects

Is a recession good or bad for people's health?

Readers of Canadian Medicine have already had a taste of this question, in two recent articles: last month in "Economic turmoil is hurting Canadians' health: CMA" and then this month in "Maybe the recession was good for healthcare, after all". In the former, we cited a survey in which Canadians self-reported cutbacks on out-of-pocket health and nutritional spending and exercise. And in the latter, we noted a recent infusion of cash to healthcare infrastructure via federal stimulus spending.

So which is it: a recession is healthful or a recession is harmful?

Well, that very question is examined in a new review published this month in the Canadian Medical Association Journal by University of Washington public-health professor and emergency physician (and University of Toronto grad) Dr Stephen Bezruchka (right), who found that "contrary to what might have been expected, economic downturns during the 20th century were associated with declines in mortality rates."

Dr Bezruchka's paper is worth a full read, but I'll point out for you a few of the most interesting items in the paper:

  • The "procyclical" (positively related) relationship between recession and decreased mortality rates was less pronounced in countries like the United States and Canada which spend less than many European nations on social programs.
  • "Health care has not been found to be a major factor in producing health in populations."
  • This is a simplification of his point, but in essence he posits that higher unemployment = less money = less money to buy cigarettes and alcohol with, and less overeating. (This logic seems questionable to me, but it's something to ponder nonetheless.)
  • Work can be stressful, and unemployment can relieve pregnant women's stress. (Highly questionable, in my opinion.)
  • Is Dr Bezruchka a socialist? See especially his assertion that redistributing wealth from rich countries to poor ones would actually be of longterm benefit to the health of everyone, from countries both rich and poor, and the claim that the "current economic crisis offers an opportunity for rich countries to rethink the social purposes of their economies."
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